Table 2 Concentrations of pneumococcal polysaccharide antigen serotype-specific IgG antibodies and opsonization indices in the RA treatment groups before and after 23-valent pneumococcal polysaccharide vaccination

6B

Before

0.84(0.58 to 1.11)

1.42(0.86 to 1.97)

1.12(0.80 to 1.45)

After

4.05(2.13 to 5.97)*

4.36(2.17 to 6.55)*

2.29(0.76 to 3.83)

Fold increase

2.38(1.41 to 5.62)

1.75(1.15 to 3.11)

1.41(0.87 to 3.09)

23F

Before

1.17(0.85 to 1.48)

1.79(1.33 to 2.25)

1.22(0.79 to 1.65)

After

11.61(4.16 to 19.07)*

7.41(4.48 to 10.33)*

4.61(2.95 to 6.27)*

Fold increase

3.36(1.85 to 9.42)

2.00(1.27 to 5.48)

2.45(1.23 to 7.44)

6B

Before

17.24(10.96 to 23.53)

150.79(14.85 to 286.74)

61.55(13.78 to 109.32)

After

981.15(407.24 to 1555.05)*

584.29(270.29 to 898.28)*

1345.19(383.97 to 2306.41)*

Fold increase

10.22(1.92 to 79.48)

2.57(1.22 to 22.40)

14.83(2.93 to 163.03)

23F

Before

63.21(−6.79 to 133.20)

52.11(14.04 to 90.18)

138.40(−87.83 to 364.63)

After

713.49(307.97 to 1119.01)*

724.56(336.93 to 1112.19)*

887.76(172.11 to 1603.42)*

Fold increase

6.86(2.50 to 27.14)

3.75(1.47 to 38.32)

2.97(1.37 to 76.09)