Parity influences the severity of ACPA-negative early rheumatoid arthritis: a cohort study based on the Swedish EIRA material

Table 4 Logistic regression for parous women compared to nulliparous women

Outcome measure above median	ACPA-negative RA
Outcome measure above median	Aged 18 − 44	Aged 45 − 70
	OR (95 % CI), p-value	OR (95 % CI), p-value
DAS28
Baseline	1.87 (0.62 to 5.69), p = 0.27	0.37 (0.18 to 0.80), p = 0.011
3 months	4.96 (1.37 to 18.1), p = 0.015	0.51 (0.24 to 1.08), p = 0.08
6 months	2.66 (0.78 to 9.15), p = 0.12	0.37 (0.16 to 0.85), p = 0.018
12 months	4.49 (1.37 to 14.7), p = 0.013	0.89 (0.44 to 1.77), p = 0.97
24 months	3.56 (1.07 to 11.9), p = 0.039	0.67 (0.30 to 1.50), p = 0.33
HAQ
Baseline	0.58 (0.20 to 1.69), p = 0.32	0.53 (0.26 to 1.07), p = 0.08
3 months	3.04 (0.90 to 10.3), p = 0.07	1.29 (0.62 to 2.67), p = 0.50
6 months	2.42 (0.71 to 8.23), p = 0.16	1.01 (0.47 to 2.14), p = 0.99
12 months	7.92 (2.02 to 31.0), p = 0.003	1.15 (0.57 to 2.33), p = 0.69
24 months	2.14 (0.65 to 7.06), p = 0.21	0.95 (0.42 to 2.17), p = 0.90

Logistic regression adjusted for age at inclusion in the Epidemiological Investigation of Rheumatoid Arthritis (EIRA), with the odds ratio (OR) of having an outcome measure (DAS28 and HAQ) higher than median for a parous woman. ACPA Anti-citrullinated protein antibody, CI confidence interval, DAS28 Disease activity score 28, HAQ Health assessment questionnaire

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