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Table 4 Comparison of HRpQCT and BMD among patients with AS based on sex, mSASSS, and HLA-B27

From: Alterations of bone mineral density, bone microarchitecture and strength in patients with ankylosing spondylitis: a cross-sectional study using high-resolution peripheral quantitative computerized tomography and finite element analysis

Variable Total Sex mSASSS HLA-B27
(N = 53) Men Women mSASSS > 0 mSASSS = 0 HLA-B27(+) HLA-B27(−)
(n = 29) (n = 24) (n = 28) (n = 25) (n = 36) (n = 16)
HRpQCT at radius
 Trabecular vBMD (mg/cm3) 165.3 ± 45.7 186.1 ± 39.6* 140.0 ± 40.0 168.8 ± 54.4 161.3 ± 34.2 175.7 ± 39.9 142.8 ± 52.3
 Cortical vBMD (mg/cm3) 854.7 ± 66.2 826.8 ± 51.8* 864.0 ± 55.2 821.6 ± 57.8** 868.4 ± 43.1 845.3 ± 59.2 834.0 ± 90.9
 Total vBMD (mg/cm3) 315.4 ± 64.4 322.5 ± 62.8 306.8 ± 66.7 303.42 ± 74.28 328.88 ± 49.49 324.0 ± 57.5 300.3 ± 77.4
 Trabecular number (/mm3) 2.02 ± 0.34 2.13 ± 0.24* 1.86 ± 0.43 1.99 ± 0.44 2.04 ± 0.25 2.07 ± 0.29 1.89 ± 0.48
 Trabecular thickness (mm) 0.068 ± 0.012 0.073 ± 0.012* 0.062 ± 0.010 0.069 ± 0.013 0.066 ± 0.011 0.071 ± 0.01 0.061 ± 0.01
 Trabecular separation (mm) 0.457 ± 0.185 0.402 ± 0.061* 0.523 ± 0.254 0.479 ± 0.246 0.432 ± 0.068 0.423 ± 0.08 0.535 ± 0.31
 BV/TV (%) 0.138 ± 0.038 0.155 ± 0.033* 0.117 ± 0.033 0.141 ± 0.045 0.134 ± 0.029 0.147 ± 0.03 0.119 ± 0.40
 Cortical thickness (mm) 0.765 ± 0.153 0.748 ± 0.148 0.786 ± 0.159 0.715 ± 0.159** 0.821 ± 0.126 0.770 ± 0.165 0.760 ± 0.160
 Cortical porosity (%) 0.020 (0.010–0.025) 0.022 (0.018–0.026)* 0.010 (0.008–0.020)* 0.021 (0.019–0.027) ** 0.012 (0.009–0.018) 0.020 (0.016–0.024) 0.016 (0.009–0.023)
 Stiffness (N/mm) 1.4 ± 0.4 1.4 ± 0.4 1.3 ± 0.4 1.3 ± 0.04 1.5 ± 0.4 1.4 ± 0.4 1.3 ± 0.5
 Stress (MPa) 27.7 ± 9.4 28.72 ± 9.35 26.38 ± 9.57 26.0 ± 9.9 29.5 ± 8.7 28.8 ± 8.9 25.8 ± 10.7
HRpQCT at tibia
 Trabecular vBMD (mg/cm3) 159.9 ± 43.7 176.6 ± 38.5* 139.8 ± 41.9 162.8 ± 44.8 157.4 ± 43.5 170.9 ± 40.7 136.9 ± 43.4
 Total vBMD (mg/cm3) 296.4 ± 55.5 302.9 ± 46.0 288.5 ± 65.1 285.1 ± 57.2 308.2 ± 52.1 309.4 ± 39.3 272.5 ± 74.8
 Cortical vBMD (mg/cm3) 843.7 ± 56.1 848.4 ± 43.4 862.2 ± 86.7 835.2 ± 79.3** 876.9 ± 39.1 865.4 ± 50.8 834.0 ± 91.0
 Trabecular number (per mm3) 1.89 ± 0.45 2.05 ± 0.29* 1.70 ± 0.533 1.95 ± 0.42 1.84 ± 0.47 1.96 ± 0.42 1.71 ± 0.49
 Trabecular thickness (mm) 0.07 ± 0.01 0.070 ± 0.014 0.071 ± 0.015 0.070 ± 0.013 0.073 ± 0.015 0.073 ± 0.014 0.070 ± 0.011
 Trabecular separation (mm) 0.50 ± 0.23 0.43 ± 0.07* 0.60 ± 0.31 0.47 ± 0.13 0.53 ± 0.29 0.46 ± 0.13 0.60 ± 0.35
 BV/TV (%) 0.133 ± 0.036 0.147 ± 0.032* 0.117 ± 0.035 0.131 ± 0.037 0.136 ± 0.036 0.143 ± 0.034 0.114 ± 0.036
 Cortical thickness (mm) 0.744 ± 0.180 0.695 ± 0.137* 0.804 ± 0.208 0.691 ± 0.182** 0.804 ± 0.161 0.766 ± 0.185 0.705 ± 0.169
 Cortical porosity (%) 0.049 (0.035–0.067) 0.061 (.044–0.075)** 0.039 (0.029–0.056)** 0.062 (0.045–0.091)** 0.040 (0.033–0.056) 0.047 (0.032–0.070) 0.056 (0.035–0.071)
 Stiffness (N/mm) 1.51 ± 0.42 1. 6 ± 0.3 1.5 ± 0.4 1.6 ± 0.3 1.5 ± 0.4 1.6 ± 0.3 1.4 ± 0.4
 Stress (MPa) 31.6 ± 9.1 32.7 ± 8.0 31.1 ± 9.5 30.6 ± 8.7 33.5 ± 8.5 33.8 ± 7.2 28.8 ± 10.4
 L1–L4 BMD 0.994 ± 0.179 1.018 ± 0.163 0.964 ± 0.198 1.001 ± 0.214 0.986 ± 0.138 1.024 ± 0.182 0.944 ± 0.161
 Total hip BMD 0.904 ± 0.149 0.943 ± 0.125* 0.858 ± 0.165 0.887 ± 0.158 0.921 ± 0.140 0.925 ± 0.123 0.857 ± 0.197
 Femoral neck BMD 0.767 ± 0.142 0.795 ± 0.153 0.733 ± 0.124 0.735 ± 0.125 0.798 ± 0.153 0.786 ± 0.130 0.727 ± 0.169
 Distal 1/3 radius BMD 0.740 ± 0.127 0.802 ± 0.067* 0.659 ± 0.142 0.771 ± 0.080 0.708 ± 0.156 0.764 ± 0.088 0.679 ± 0.185
 Ultradistal radius BMD 0.477 ± 0.078 0.505 ± 0.079* 0.441 ± 0.061 0.481 ± 0.086 0.472 ± 0.069 0.488 ± 0.084 0.453 ± 0.059
  1. Data expressed as mean ± standard deviation, median (interquartile range) or number (% N) unless specified otherwise
  2. *p <0.05, men vs. women
  3. **p <0.05, high mSASSS (mSASSS >0) vs. normal mSASSS
  4. p <0.05, HLA-B27(+) vs. HLA-B27(−)
  5. AS ankylosing spondylitis, BMD bone mineral density, BV/TV bone volume/trabecular volume, HRpQCT high-resolution peripheral quantitative computerized tomography, mSASSS, modified Stoke Ankylosing Spondylitis Spine Score, vBMD volumetric bone mineral density
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