Fig. 1
From: Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β
Hedgehog pathway activation does not increase the expression of a disintegrin and matrix metalloproteinase with thrombospondin motif (ADAMTS-5) and matrix metalloproteinase-13 (MMP-13) in bovine articular chondrocytes. After 24 hours of stimulation with r-Ihh, changes in the gene expression of (a) Gli1 and Ptch1 and (b) ADAMTS-5 and MMP-13 were measured. Data are mean fold-change normalised to untreated controls with standard deviation error bars (n = 9 from three separate donors). *Statistically significant differences relative to untreated controls, *P <0.05, **P ≤0.01, and ***P ≤0.001. r-Ihh recombinant Ihh