Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β

Table 1 The doses and modes of actions of hedgehog pharmaceuticals

Drug name	Molecular weight	Mechanism of action	Dose
r-Ihh	20,000 Da	Binds to Ptch1, causing Ptch1 inhibition and Smo activation [5, 41]	1 μg/mL
Cyclopamine	411.6 Da	Smo antagonist [20–24]	Bovine: 10 μM
Cyclopamine	411.6 Da	Smo antagonist [20–24]	Human: 20 μM
KAAD-cyclopamine	698 Da	Smo antagonist [24, 42, 43]	1 μM
SANT-1	373.5 Da	Smo antagonist [20, 23, 44]	1 μM
GANT61	429.6 Da	Gli antagonist [39, 45, 46]	10 μM

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