Table 1 The doses and modes of actions of hedgehog pharmaceuticals
From: Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β
| Drug name | Molecular weight | Mechanism of action | Dose |
|---|---|---|---|
| r-Ihh | 20,000 Da | Binds to Ptch1, causing Ptch1 inhibition and Smo activation [5, 41] | 1 μg/mL |
| Cyclopamine | 411.6 Da | Smo antagonist [20–24] | Bovine: 10 μM |
| Human: 20 μM | |||
| KAAD-cyclopamine | 698 Da | Smo antagonist [24, 42, 43] | 1 μM |
| SANT-1 | 373.5 Da | Smo antagonist [20, 23, 44] | 1 μM |
| GANT61 | 429.6 Da | Gli antagonist [39, 45, 46] | 10 μM |