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Table 1 The doses and modes of actions of hedgehog pharmaceuticals

From: Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β

Drug name Molecular weight Mechanism of action Dose
r-Ihh 20,000 Da Binds to Ptch1, causing Ptch1 inhibition and Smo activation [5, 41] 1 μg/mL
Cyclopamine 411.6 Da Smo antagonist [2024] Bovine: 10 μM
Human: 20 μM
KAAD-cyclopamine 698 Da Smo antagonist [24, 42, 43] 1 μM
SANT-1 373.5 Da Smo antagonist [20, 23, 44] 1 μM
GANT61 429.6 Da Gli antagonist [39, 45, 46] 10 μM
  1. Ptch 1 patched 1, r-Ihh recombinant Indian hedgehog, Smo smoothened