Skip to main content
Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: High-mobility group box 1 potentiates antineutrophil cytoplasmic antibody-inducing neutrophil extracellular traps formation

Fig. 1

Neutrophils pretreated with HMGB1 showed greater ability to produce NETs in the presence of ANCA-positive IgG. NETs induced by MPO-ANCA-positive IgG (a) or PR3-ANCA-positive IgG (b) were measured by cell-free DNA concentration in HMGB1-pretreated neutrophils. c and d were representative histograms showing that the percentage of NETs formation induced by MPO-ANCA-positive IgG and PR3-ANCA-positive IgG in HMGB1-pretreated neutrophils. Bars represent mean ± SD of repeated measurements on neutrophils of 9–12 independent experiments and 9 donors. ANCA antineutrophil cytoplasmic antibody, HMGB1 high-mobility group box 1, IgG immunoglobulin G, MPO myeloperoxidase, NETs neutrophil extracellular traps, PR3 proteinase 3, PMA phorbol myristate acetate

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us