Fig. 1

Attenuated CFA-induced chronic mechanical hypersensitivity and oedema in TRPA1 KO mice. CFA-evoked (a) mechanical hypersensitivity (n = 14–17/group), (b) oedema (n = 14–17/group), (c) thermal hypersensitivity (n = 7–8/group), and (d) cold sensitivity (n = 7–8/group) of the hindpaw of TRPA1 KO mice as compared to their WT counterparts throughout the 21-day experimental period. Data are shown as means ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001 (vs. WT ipsilateral paw), ^### p < 0.001 (vs. respective contralateral paw); two-way ANOVA followed by Bonferroni’s multiple comparison test. ANOVA analysis of variance, CFA complete Freund’s adjuvant, KO knockout, SEM standard error of the mean, TRPA1 transient receptor potential akyrin 1, WT wildtype