Fig. 4

Decreased MIA-induced pain behaviours in TRPA1 KO mice. MIA-evoked (a) mechanical hypersensitivity, (b) percentage of spontaneous weight distribution and (c-d) mediolateral and anteroposterior diameters of the ipsilateral knee joints of TRPA1 KO mice as compared to their WT counterparts throughout the 21-day experimental period. Results are shown as means ± SEM of n = 10–15 mice/group, *p < 0.05 (vs. WT ipsilateral limb), ^# p < 0.05, ^### p < 0.001 (vs. respective contralateral limb), two-way ANOVA followed by Bonferroni’s multiple comparison test. ANOVA analysis of variance, KO knockout, MIA monosodium iodoacetate, SEM standard error of the mean, TRPA1 transient receptor potential akyrin 1, WT wildtype