Fig. 6

No change of acute carrageenan-evoked hypersensitivity and paw oedema in TRPA1 KO mice. Carrageenan-induced (a) mechanical hypersensitivity (n = 12–13/group), (b) oedema (n = 12–13/group), (c) thermal hypersensitivity (n = 12–13/group), and (d) cold sensitivity (n = 7–8/group) of the hindpaw of TRPA1 KO mice as compared to their WT counterparts throughout the 24-hour experimental period. Data are shown as means ± SEM, ^### p < 0.001 (vs. respective contralateral paw); two-way ANOVA followed by Bonferroni’s multiple comparison test. ANOVA analysis of variance, KO knockout, MIA monosodium iodoacetate, SEM standard error of the mean, TRPA1 transient receptor potential akyrin 1, WT wildtype