Fig. 7

CFA-induced acute knee joint pain and oedema are not influenced by TRPA1 deletion. CFA-evoked acute (a) mechanical hypersensitivity, (b-c) mediolateral and anteroposterior diameters of the ipsilateral knee joints of TRPA1 KO mice as compared to their WT counterparts throughout the 24-hour experimental period. Results are shown as means ± SEM of n = 11–12 mice/group, ^# p < 0.05 (vs. respective contralateral limb), two-way ANOVA followed by Bonferroni’s multiple comparison test. ANOVA analysis of variance, CFA complete Freund’s adjuvant, KO knockout, SEM standard error of the mean, TRPA1 transient receptor potential akyrin 1, WT wildtype