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Table 1 Summary of functional and morphological alterations in different inflammation models in TRPA1 KO mice as compared to their WTs

From: Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: in vivo study using TRPA1-deficient mice

  1. In TRPA1 KO mice, CFA-induced chronic mechanical hypersensitivity, paw swelling, neutrophil MPO-activation, plasma extravasation and histopathological changes, as well as MIA-evoked mechanical hypersensitivity and spontaneous weight distribution were significantly reduced. In contrast, thermal hypersensitivity and cold sensitivity in the chronic CFA-model, knee diameter, histopathological changes in the MIA-model, and mechanical and thermal hypersensitivity, oedema and cold sensitivity in the carrageenan- and CFA-induced acute models did not significantly differ between the WT and KO groups
  2. CFA complete Freund’s adjuvant, MIA monosodium iodoacetate, MPO myeloperoxidase TRPA1 transient receptor potential akyrin 1, KO knockout, WT wildtype
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Arthritis Research & Therapy

ISSN: 1478-6362

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