Fig. 3

Classification and regression tree analysis (CART) for prediction of early responders defined as early non-responders. The odds ratio was calculated using a 2 × 2 table. Each node is described by limits above the node. Blue bars and orange bars indicate numbers of early non-responders and responders, respectively. CTX-I C-terminal telopeptide of type I collagen, OC osteocalcin, C2M matrix metalloproteinase-derived fragments of type II collagen, BL baseline and pct percentage change from baseline to 4 weeks