Fig. 1From: Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapyCorrelations between clinical disease activity indices and the expression of 51,452 probe sets in 65 synovial biopsy samples from untreated and treated patients with rheumatoid arthritis (RA). a Distribution of Pearson r correlation coefficients between disease activity score in 28 joints assessed by C-reactive protein level (DAS28-CRP)/simplified disease activity index (SDAI)/clinical disease activity index (CDAI) and synovial gene expression levels. b Overlap between probe sets displaying a Pearson r correlation coefficient >0.5 with DAS28-CRP, SDAI and CDAI. c, d Gene set enrichment analyses and eigenvalues calculations using probe sets displaying a Pearson r correlation coefficient >0.5 with DAS28-CRP indicate that the majority of them are downregulated by tocilizumab in synovial tissue in RA (c), and a large proportion are induced by TNFα in cultured fibroblast-like synoviocytes (FLS) or monocytes (d). e Pathway analyses (http://david.abcc.ncifcrf.gov) indicate that transcripts displaying a Pearson r correlation coefficient >0.5 with DAS28-CRP are significantly enriched in genes associated with T cell activation, inflammatory responses, antigen presentation and lysosomes. Probe sets belonging to these pathways are downregulated by tocilizumab in RA synovial tissueBack to article page