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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy

Fig. 4

Quantification of GADD45B and PDE4D immunostaining in baseline synovial biopsies from patients with early rheumatoid arthritis (RA), osteoarthritis and psoriatic arthritis. a Needle-arthroscopic synovial biopsies from untreated patients with early RA (n = 46), psoriatic arthritis (n = 9) and osteoarthritis (n = 12) were stained with polyclonal antibodies directed at GADD45B and PDE4D. Data are represented as the ratio of GADD45B or PDE4D surface staining to staining of the nuclei. Horizontal bars represent the median values. P values were calculated using Kruskal–Wallis test. b GADD45B and PDE4D immunostaining in needle-arthroscopic synovial biopsies obtained in patients with early RA prior to initiation of therapy. Patients are distributed as good, moderate and poor responders to therapy according to European League Against Rheumatism (EULAR) response criteria at 6 months. P values were calculated using Kruskal–Wallis test. c GADD45B and PDE4D immunostaining in needle-arthroscopic (sub-group of population displayed in a and b) and ultrasound-guided biopsies obtained in patients with early RA prior to initiation of methotrexate therapy. Patients are distributed as responders or non-responders according to EULAR response criteria at 6 months. P values were calculated using Mann–Whitney test

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Arthritis Research & Therapy

ISSN: 1478-6362

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