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Table 3 Cytokines, inflammatory markers, and clinical parameters in active-AS patients undergoing anti-TNF therapy vs. healthy controls

From: IL-23/Th17 axis is not influenced by TNF-blocking agents in ankylosing spondylitis patients

  Active-AS patients Healthy controls (n = 47)
Variable Baseline (n = 47) 12 months (n = 47) 24 months (n = 47) p valuea   p valueb
ESR (mm/hour) 29.70 ± 23.32 9.59 ± 12.10 10.53 ± 13.90 <0.001 NA  
CRP (mg/l) 29.71 ± 39.56 7.57 ± 13.50 5.13 ± 6.23 <0.001 NA  
mSASSS 15.83 ± 18.73 NA 19.49 ± 19.61 <0.001 NA  
ASDAS-CRP 3.93 ± 1.04 2.08 ± 1.12 1.93 ± 1.11 <0.001 NA  
BASFI 5.80 ± 2.33 3.60 ± 2.97 3.18 ± 2.95 <0.001 NA  
BASMI 4.53 ± 2.70 3.70 ± 2.72 3.34 ± 2.56 <0.001 NA  
ASQoL 12.59 ± 4.83 6.57 ± 5.51 5.83 ± 5.81 <0.001 NA  
NSAID intake (0–100) 70.26 ± 44.78 62.43 ± 47.56 45.16 ± 46.37 <0.01 NA  
IL-17A (pg/ml) 1.62 (1.06–2.98) 1.58 (1.14–3.52) 1.69 (0.78–3.46) 0.78 1.57 (1.04–2.17) 0.96
IL-22 (ng/ml) 0.00 (0.00–0.00) 0.00 (0.00–0.00) 0.00 (0.00–0.00) 0.87 0.00 (0.00–0.00) 0.59
IL-23 (ng/ml) 0.08 (0.04–0.17) 0.04 (0.02–0.17) 0.06 (0.03–0.15) 0.38 0.02 (0.00–0.05) <0.001
PGE2 (pg/ml) 19.46 (5.41–102.58) 23.73 (4.72–102.82) 35.50 (5.88–75.82) 0.98 7.66 (3.30–30.32) 0.03
  1. Values expressed as mean ± standard deviation or median (25–75 % interquartile range)
  2. Nonparametric tests were performed for data that failed the normal distribution
  3. aActive-AS at baseline vs. 12 months vs. 24 months by analysis of variance
  4. bActive-AS after 24 months TNF blockade vs. healthy controls
  5. AS ankylosing spondylitis, ASDAS-CRP Ankylosing Spondylitis Disease Activity Score-C-reactive protein, ASQoL Ankylosing Spondylitis Quality of life, BASFI Bath Ankylosing Spondylitis Functional Index, BASMI Bath Ankylosing Spondylitis Metrology Index, CRP C-reactive protein, ESR erythrocyte sedimentation rate, IL interleukin, mSASSS modified Stoke Ankylosing Spondylitis Spine Score, NA not analyzed, NSAID nonsteroidal anti-inflammatory drug, PGE2 prostaglandin E2, TNF tumor necrosis factor