The interleukin-20 receptor axis in early rheumatoid arthritis: novel links between disease-associated autoantibodies and radiographic progression

Table 2 Correlations between baseline plasma concentrations of the IL-20R cytokines and clinical parameters, response rates, and radiographic progression

	Baseline cytokine concentration
	IL-19	IL-20	IL-24
Disease activity scores^a
Patient global	0.053 (0.59)	−0.061 (0.46)	0.029 (0.73)
Physician global	−0.044 (0.59)	0.042 (0.61)	0.067 (0.41)
HAQ	−0.013 (0.88)	0.070 (0.39)	0.084 (0.31)
DAS28CRP	−0.015 (0.85)	0.030 (0.72)	0.071 (0.38)
Response rates^b
ACR20	−0.093 (0.28)	0.038 (0.66)	0.018 (0.83)
ACR 50	−0.035 (0.69)	0.060 (0.48)	0.038 (0.66)
ACR70	−0.016 (0.85)	0.026 (0.76)	0.055 (0.52)
ACR90	−0.038 (0.66)	−0.021 (0.81)	−0.035 (0.68)
Radiographic progression^c
Total Sharp score	0.04 (0.63)	0.27 (0.001)	0.23 (0.005)
Erosions	−0.014 (0.87)	0.14 (0.094)	0.17 (0.047)
Joint space narrowing	0.05 (0.55)	0.16 (0.062)	0.10 (0.23)

Data were analyzed using the Spearman’s correlation. Numbers indicate Spearmans Rho with P value in parenthesis. Bold numbers indicate P < 0.05. ^aDisease activity scores at baseline. ^bResponse after 12 months of treatment. ^cRadiographic progression after 12 months of treatment (12 months – baseline)
ACR American College of Rheumatology, DAS28CRP disease activity score 28 based on C-reactive protein, HAQ health assessment questionnaire, IL interleukin

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