Fig. 6

Prophylactic treatment with anti-colony stimulating factor-1 receptor (anti-CSF1R) prevents pathological progression in collagen-induced arthritis (CIA). a Daily global arthritic scores for mice treated intraperitoneally every 3 days with vehicle, Enbrel, or muAb5. Treatment continued three times weekly from day 0 with control vehicle (triangles), Enbrel (10 mg/kg) (circles) or muAb5 (30 mg/kg) (squares). b Representative images of pathological appearances of the joints in the indicated treatment group, visualized by H&E staining. Note the representative areas of synovial cellular infiltration and pannus formation (arrows). c Inflammation (I), pannus formation (PF), cartilage damage (CD), and bone damage (BD) scores for mice in each treatment group. Data are mean ± standard error of the mean (SEM) for each group (n = 12 animals per group). ^# P < 0.05 vs vehicle and **P < 0.01. d, e Band 5 tartrate-resistant acid phosphatase isoform b (TRAP5b) plasma levels (d) and number of F4/80-positive cells in five × 200 fields (e) in the inflamed joints of mice in each treatment group. Symbols represent values obtained from individual animals, bars represent the mean, and error bars indicate the SEM. ^# P < 0.05 vs naive and ^### P < 0.001 vs naïve. ***P < 0.001