Fig. 7

Therapeutic treatment with anti-colony stimulating factor-1 receptor (anti-CSF1R) suppresses bone destruction and pannus formation in collagen-induced arthritis (CIA). a Histopathological assessment of CIA in mice treated with vehicle, Enbrel, or muAB5 after the initiation of arthritis. *P < 0.05 and **P < 0.01 vs vehicle. I inflammation, PF pannus formation, CD cartilage damage, BD bone damage. b, c Band 5 tartrate-resistant acid phosphatase isoform b (TRAP5b) plasma levels (b) and number of F4/80-positive cells in five × 200 fields (c) in the inflamed joints of mice in each treatment group. Symbols represent values obtained from individual animals, bars represent the mean, and error bars indicate the standard error of the mean. **P < 0.01 vs vehicle and ^### P < 0.001 vs naïve. ***P < 0.001