Fig. 3

Type II collagen (CII)-specific T cell responses in vitro and anti-CII antibody levels in embryonic stem cell-derived mesenchymal stromal cells (hESC-MSC)-treated mice. a Proliferation and cytokine production in response to CII by inguinal lymph node cells from hESC-MSC and phosphate-buffered saline (PBS)-treated mice with established collagen-induced arthritis. Data represent the mean ± the standard error of the mean of the experimental groups. b Comparable levels of anti-CII IgG1 and IgG2a were measured in sera from control and hESC-MSC-treated mice. Data shown are values from individual mice and the mean of experimental groups. Statistical differences were analyzed by the Mann-Whitney U test and no significant differences were found. NS non-stimulated