Fig. 1

Phagocytes from patients with anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) produced fewer reactive oxygen species (ROS) than phagocytes from healthy blood donors. The capacities of polymorphonuclear leukocytes (PMN) (a) or monocytes (b) from healthy controls (HC) (n = 112), patients with AAV (n = 104), and patients with systemic lupus erythematosus (SLE) (n = 26) (only PMN) to produce ROS upon activation with phorbol 12-myristate 13-acetate (PMA) or opsonized E. coli were investigated using flow cytometry. The amount of ROS produced is shown as geometric mean fluorescence intensity (geoMFI). The two-sided Mann-Whitney test was used to calculate the level of significance. Horizontal lines represent the median value of each dataset