Fig. 6

Effects of selective tropomyosin-receptor-kinase A (TrkA) inhibitor AR786 on ankle pathology following collagen-induced arthritis. Collagen-induced arthritis was associated with increased total histological score (a), synovial inflammation (b), pannus formation (c), cartilage damage (d), bone resorption (e) and periosteal bone formation (f). AR786 30 mg/kg orally twice daily from the time of collagen challenge was associated with reduced total histological score and each of its components after 17 days. Ibuprofen 35 mg/kg orally once daily also significantly reduced total histological scores, inflammation, pannus, cartilage damage and bone resorption sub-scores. Kruskal-Wallis statistics all >19, p ≤ 0.0002. Comparisons versus vehicle-treated arthritic animals, *p < 0.05, **p < 0.01, ***p < 0.001, and versus naïve controls ⁺ p < 0.05, ⁺⁺ p < 0.01, ⁺⁺⁺ p < 0.001. Horizontal bars represent median values