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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Antibodies to carbamylated α-enolase epitopes in rheumatoid arthritis also bind citrullinated epitopes and are largely indistinct from anti-citrullinated protein antibodies

Fig. 3

Homocitrullinated CEP-1 peptide (Carb-CEP-1) reactivity results from cross-reactive anti-CEP-1 antibodies. To assess cross-reactivity between CEP-1 and carb-CEP-1, serum from patients positive for either anti-CEP-1 antibodies only (n = 4) or for anti-carb-CEP-1 antibodies only (n = 4), and serum from patients positive for both anti-CEP-1 and anti-carb-CEP-1 antibodies (n = 4), were pre-absorbed by incubating with either dilution buffer, CEP-1 peptide or carb-CEP-1 peptide. Levels of anti-CEP-1 (a) and anti-carb-CEP-1 (b) antibodies were subsequently measured by ELISA, and presented as optical density (OD). EIRA Swedish Epidemiological Investigation of Rheumatoid Arthritis cohort

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Arthritis Research & Therapy

ISSN: 1478-6362

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