Table 2 Disease characteristics at baseline and week 36, according to week-36 concordance category

DAS28

BL

4.4 (0.4)

4.4 (0.4)

4.5 (0.4)

0.2356

Week 36

2.8 (1.1)

2.2 (0.9)

3.1 (1.3)

<0.0001

Δ BL to wk 36

−1.6 (1.0)

−2.2 (0.9)

−1.4 (1.3)

<0.0001

CRP, mg/L

BL

9.9 (13.9)

13.4 (17.7)

8.1 (7.1)

0.0256

Week 36

6.4 (8.2)

6.4 (7.9)

7.6 (12.0)

0.8036

Δ BL to wk 36

−3.4 (14.7)

−7.0 (17.0)

−0.4 (9.8)

0.0123

CRP, mg/L, median

BL

4.6

5.9

4.0

Week 36

4.0

4.0

4.0

Δ BL to wk 36

0

−1

0

ESR, mm/h

BL

21.0 (13.9)

22.9 (13.1)

20.2 (10.5)

0.1652

Week 36

13.4 (13.1)

11.8 (9.5)

15.0 (10.5)

0.1083

Δ BL to wk 36

−7.6 (11.2)

−11.1 (12.6)

−5.2 (10.7)

0.0006

TJC (0–28)

BL

5.0 (2.6)

5.0 (2.8)

6.0 (3.5)

0.3502

Week 36

1.8 (2.5)

1.1 (2.2)

4.0 (5.6)

<0.0001

Δ BL to wk 36

−3.3 (3.4)

−4.0 (3.2)

−2.0 (6.3)

0.0039

SJC (0–28)

BL

3.5 (2.3)

4.0 (2.7)

4.8 (3.3)

0.0227

Week 36

1.1 (1.9)

0.9 (1.9)

3.9 (4.3)

<0.0001

Δ BL to wk 36

−2.3 (2.5)

−3.1 (2.6)

−0.9 (5.0)

<0.0001

Duration of morning joint stiffness, min

BL

227 (384)

158 (314)

242 (472)

0.0453

Week 36

78 (164)

39 (166)

67 (144)

0.0191

Δ BL to wk 36

−148 (370)

−120 (324)

−175 (515)

0.5315

BPI (0–10)

BL

4.7 (2.1)

3.7 (1.9)

3.9 (2.1)

<0.0001

Week 36

3.2 (2.2)

1.1 (1.3)

1.8 (1.6)

<0.0001

Δ BL to wk 36

−1.5 (2.4)

−2.6 (2.1)

−2.1 (2.5)

<0.0001

HAQ-DI (0–3)

BL

1.2 (0.6)

1.1 (0.6)

1.2 (0.7)

0.1458

Week 36

0.9 (0.6)

0.5 (0.5)

0.7 (0.6)

<0.0001

Δ BL to wk 36

−0.3 (0.6)

−0.7 (0.5)

−0.5 (0.5)

<0.0001

FACIT-fatigue^b (0–52)

BL

30.8 (9.3)

33.7 (9.4)

29.7 (10.0)

0.0006

Week 36

35.7 (9.5)

43.1 (8.0)

39.1 (9.8)

<0.0001

Δ BL to wk 36

4.9 (9.4)

9.4 (8.8)

9.3 (11.4)

<0.0001

CDAI (0–76)

BL

18.1 (4.5)

17.6 (5.0)

21.2 (6.3)

0.0049

Week 36

8.7 (5.8)

4.7 (5.1)

13.6 (10.1)

<0.0001

Δ BL to wk 36

−9.5 (6.5)

−12.9 (6.4)

−7.6 (12.0)

<0.0001

SDAI (0–86)

BL

19.2 (4.6)

18.9 (5.2)

22.0 (6.2)

0.0382

Week 36

9.4 (5.9)

5.3 (5.3)

14.4 (10.5)

<0.0001

Δ BL to wk 36

−9.8 (6.4)

−13.6 (6.5)

−7.6 (12.2)

<0.0001

Patient global assessment (0–10)

BL

5.5 (1.6)

4.6 (1.7)

5.2 (2.0)

<0.0001

Week 36

4.5 (1.8)

1.5 (1.2)

1.4 (1.1)

<0.0001

Δ BL to wk 36

−1.0 (2.2)

−3.1 (1.9)

−3.8 (2.2)

<0.0001

Physician global assessment (0–10)

BL

4.2 (1.4)

4.0 (1.3)

5.2 (1.5)

0.0002

Week 36

1.4 (1.2)

1.3 (1.1)

4.3 (2.1)

<0.0001

Δ BL to wk 36

−2.9 (1.6)

−2.7 (1.5)

−0.9 (2.9)

<0.0001

Patient general health VAS

BL

47.8 (16.9)

40.9 (15.9)

45.7 (22.8)

<0.0001

Week 36

36.9 (19.1)

12.4 (13.3)

14.7 (14.4)

<0.0001

Δ BL to wk 36

−11.1 (22.4)

−28.5 (18.8)

−31.1 (22.6)

<0.0001