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Table 2 Serum proteins positively correlated with ESSDAI score in patients with pSS in first cohort (n = 30)

From: Identification of definitive serum biomarkers associated with disease activity in primary Sjögren’s syndrome

Protein Spearman’s ρ P value
EPHB-2 0.65 <0.0001
CXCL13 0.60 0.0005
CD48 0.56 0.0014
β2MG 0.55 0.0018
BAFF 0.52 0.0029
TNF-R2 0.51 0.0039
LAG-3 0.49 0.0058
CD163 0.49 0.0062
PD-L2 0.47 0.0081
  1. Spearman’s rho correlation coefficient test was used to test correlation between 82 differentially expressed protein concentrations and the European League Against Rheumatism Sjögren’s Syndrome Disease Activity Index (ESSDAI) scores. EPHB-2, ephrin type-B receptor 2, CXCL13, C-X-C motif chemokine 13, β2MG β2-microglobulin, BAFF B-cell activating factor, TNF-R2 TNF receptor 2, LAG-3, lymphocyte activation gene-3, PD-L2 programmed cell death protein 1 ligand 2A P value <0.01 was considered significant