Fig. 6
From: Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice
Knockout of the ETB receptor signal reduces the activation of skin-derived fibroblasts in response to ET-1. a, b ET-1-induced fibroblast activation in WT and ETBKO mice (n = 4 or 5 each), determined by the gene expression levels of Col1α1, αSMA. Values show the mean mRNA levels relative to WT without stimulation (* p < 0.05). c Soluble collagen production from WT and ETBKO (n = 4 each) fibroblasts with or without ET-1-treatment (* p < 0.05). αSMA α-smooth muscle actin, BLM bleomycin, Col1α1 collagen 1α1, ET-1 endothelin-1, ET B KO endothelin type B receptor knockout, PBS phosphate-buffered saline, WT wild-type