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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis

Fig. 2

Dickkopf-1 (Dkk-1) is upregulated responders to rituximab (RTX) therapy. In the baseline biopsy (a, b) Dkk-1 is not expressed in the epidermis (black arrow), appendices (green arrow), and spindle-like cells (red arrows). Following RTX treatment (d, e) there is clear expression of Dkk-1 in the epidermis (black arrow), appendices (green arrow) and spindle-like cells (red arrows). Streptavidin biotin peroxidase: magnification × 20 (a, d), × 400 (b, e). Upregulation of Dkk-1 expression is associated with a decrease in collagen accumulation (prior to (c) and after (f) RTX treatment). Masson’s trichrome × 100

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Arthritis Research & Therapy

ISSN: 1478-6362

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