JAK3-STAT pathway blocking benefits in experimental lupus nephritis

Table 1 Kidney gene expression

Gene	Control	CYP	MMF	CP	p Value
C3	4.8 ± 1.6	1.61 ± 0.4^a	1.67 ± 0.2^a	2.1 ± 0.4^a	0.02
CCL2	3.5 ± 0.9	1.35 ± 0.4	2.7 ± 0.9	2 ± 0.6	NS
CCL5	1.4 ± 0.4	0.43 ± 0.1	0.9 ± 0.2	0.9 ± 0.4	NS
CD40L	1.2 ± 0.3	0.4 ± 0.1^a,b	0.8 ± 0.2	0.1 ± 0.1^a,b	0.0017
IL2	1.3 ± 0.4	0.5 ± 0.2^a	0.3 ± 0.1^a	0.2 ± 0.1^a	0.02
IL6	3.3 ± 1.7	0.3 ± 0.0^a	0.9 ± 0.3^a	0.5 ± 0.1^a	0.03
TLR9	1.5 ± 0.1	0.3 ± 0.1^a	0.5 ± 0.1^a	0.6 ± 0.1^a	0.0001
VCAM1	1.2 ± 0.1	0.8 ± 0.2	0.6 ± 0.1	0.9 ± 0.1	NS
STAT1	2.01 ± 0.2	0.66 ± 0.3^a	0.71 ± 0.1^a	0.48 ± 0.1^a	0.0001
STAT2	1.86 ± 0.1	0.82 ± 0.1^a	0.86 ± 0.1^a	0.57 ± 0.1^a	0.0001
STAT3	2.14 ± 0.4	0.92 ± 0.1^a	0.99 ± 0.2	0.98 ± 0.1^a	0.016
STAT4	2.23 ± 0.3	0.42 ± 0.1^a	0.51 ± 0.1^a	0.21 ± 0.1^a	0.0001
STAT5a	1.42 ± 0.3	0.64 ± 0.1^a	0.59 ± 0.1^a	0.62 ± 0.1^a	0.021

Abbreviations: C3, complement component 3, CCL chemokine (C-C motif) ligand, CP CP-690,550, CYP cyclophosphamide, IL interleukin, MMF mycophenolate mofetil, NS not significant, STAT signal transducer and activator of transcription, TLR Toll-like receptor, VCAM1 vascular cell adhesion molecule 1
Data presented are fold changes in 18S ribosomal RNA, house keeping gene for random target polymerase chain reaction
^aCompared with control
^bCompared with MMF

ISSN: 1478-6362