Fig. 3
![Fig. 3](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs13075-016-1044-8/MediaObjects/13075_2016_1044_Fig3_HTML.gif)
Critical role of T cells in ECFC and CFU-EC differentiation. a Depletion of T cells from ECFC or CFU-EC cultures abolished EPC differentiation. Adding back T cells restored ECFC and CFU-EC outgrowth indicating the pivotal role of T cells in promoting EPC differentiation. b No significant difference was found between HC and AAV-r regarding the fraction of circulating CD31+ T cells. c Stratifying patients according to clinical course reveals that frequent relapsers have an expanded compartment of circulating angiogenic T cells as compared to HC or patients with nonrelapsing disease course. Horizontal bars represent the mean value, error bars represent the standard of the mean. *p = 0.01, **p = 0.006. AAV-r patients in remission, CFU-EC colony-forming units-endothelial cells, ECFC endothelial cell-forming colonies, HC healthy controls, PBMC peripheral blood mononuclear cells