Fig. 6

Spinal substance P (SP) and calcitonin gene-related peptide (CGRP) concentrations 21 days after monosodium iodoacetate (MIA) injection (relative ratio (RR) mean and SD). Mean RR spinal cord concentration was normalized to the naive group. An RR of 1 indicated the concentration of normal rats from the naive group. The RR for SP and CGRP were increased in all groups (including the sham group) but had a higher peak after MIA injection. Lidocaine treatment (L) induced a lesser liberation of SP and CGRP (albeit not statistically significant for the latter) in the spinal cord of the MIA-L group. ^a,b,cSignificant inter-group statistical differences (adjusted P value <0.10)