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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Inhomogeneity of immune cell composition in the synovial sublining: linear mixed modelling indicates differences in distribution and spatial decline of CD68+ macrophages in osteoarthritis and rheumatoid arthritis

Fig. 1

Typical histologic and immunohistochemical staining patterns of RA and OA synovial tissue. H&E staining reveals an enlarged synovial lining layer (black arrows), an increased cellular density (hollow arrow) and inflammatory infiltrates (arrowhead) in RA tissue, the findings are less marked in OA tissue. CD68 and CD55 expression is predominant in the lining layer (black arrow) and upper sublining (white arrowhead) adjacent to the lining, again more pronounced in RA compared to OA, whereas CD3+ T cells are distributed equally within the sublining. CD38 expression is observed in the lining layer (black arrow) and vascular structures (*) as well as in lymphocytic infiltrates (arrowhead). vWF and MCT staining is also more pronounced within the upper lining, although the difference between RA and OA is only mild

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