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Table 4 Mean percentage of stained area in the synovial sublining

From: Inhomogeneity of immune cell composition in the synovial sublining: linear mixed modelling indicates differences in distribution and spatial decline of CD68+ macrophages in osteoarthritis and rheumatoid arthritis

  All patients RA OA Mann–Whitney U
(mean ± SD) (mean ± SD) (mean ± SD) (p value)
CD68 Upper 10.52 (±7.75) 15.89 (±6.88) 4.55 (±2.42) 0.001
  Middle 7.12 (±7.82) 12.04 (±8.05) 1.66 (±0.89) 0.001
  Lower 5.92 (±6.92) 9.85 (±7.66) 1.56 (±1.06) 0.001
  Total area 7.85 (±7.33) 12.59 (±7.30) 2.59 (±1.34) <0.001
CD3 Upper 4.79 (±7.74) 8.06 (±8.88) 0.79 (±1.11) 0.006
  Middle 4.38 (±6.27) 6.68 (±7.32) 1.58 (±3.22) 0.056
  Lower 3.56 (±5.70) 5.86 (±6.91) 0.75 (±1.15) 0.095
  Total area 4.24 (±6.05) 6.86 (±7.09) 1.04 (±1.78) 0.012
CD55 Upper 10.80 (±11.93) 15.81 (±13.61) 4.67 (±5.45) 0.012
  Middle 4.29 (±5.40) 6.46 (±6.11) 1.64 (±2.86) 0.002
  Lower 5.00 (±6.20) 7.73 (±7.21) 1.66 (±1.88) 0.007
  Total area 6.70 (±6.59) 10.00 (±7.00) 2.66 (2.92) 0.002
CD38 Upper 5.75 (±4.95) 7.43 (±4.34) 3.68 (±5.10) 0.046
  Middle 2.86 (±3.94) 3.97 (±4.55) 1.50 (±2.68) 0.038
  Lower 2.74 (±3.85) 3.60 (±4.52) 1.69 (±2.73) 0.175
  Total area 3.78 (±4.01) 5.00 (±4.16) 2.29 (±3.47) 0.046
vWF Upper 4.19 (±2.67) 4.87 (±2.77) 3.37 (±2.43) 0.295
  Middle 3.84 (±2.92) 4.52 (±2.29) 3.02 (±3.51) 0.175
  Lower 2.88 (±2.28) 3.46 (±2.39) 2.18 (±2.06) 0.175
  Total area 3.64 (±2.17) 4.28 (±1.94) 2.86 (±2.30) 0.152
MCT Upper 1.53 (±1.53) 1.53 (±1.68) 1.54 (±1.42) 0.897
  Middle 0.58 (±0.79) 0.53 (±0.73) 0.64 (±0.91) 0.696
  Lower 0.67 (±0.70) 0.66 (±0.59) 0.69 (±0.86) 0.897
  Total area 0.93 (±0.90) 0.90 (±0.85) 0.96 (±1.01) 0.829
  1. Comparison of rheumatoid arthritis (RA) and osteoarthritis (OA) by Mann–Whitney U, significant results are shown in bold. Upper layer adjacent to lining layer; lower layer with greatest distance from lining layer within the deeper synovium
  2. RA rheumatoid arthritis, OA osteoarthritis, SD standard deviation, CD68 macrophages, CD3 T cells, CD55 synovial fibroblasts, CD38 plasma cells, vWF von Willebrand factor, MCT mast cell tryptase