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Table 4 Mean percentage of stained area in the synovial sublining

From: Inhomogeneity of immune cell composition in the synovial sublining: linear mixed modelling indicates differences in distribution and spatial decline of CD68+ macrophages in osteoarthritis and rheumatoid arthritis

 

All patients

RA

OA

Mann–Whitney U

(mean ± SD)

(mean ± SD)

(mean ± SD)

(p value)

CD68

Upper

10.52 (±7.75)

15.89 (±6.88)

4.55 (±2.42)

0.001

 

Middle

7.12 (±7.82)

12.04 (±8.05)

1.66 (±0.89)

0.001

 

Lower

5.92 (±6.92)

9.85 (±7.66)

1.56 (±1.06)

0.001

 

Total area

7.85 (±7.33)

12.59 (±7.30)

2.59 (±1.34)

<0.001

CD3

Upper

4.79 (±7.74)

8.06 (±8.88)

0.79 (±1.11)

0.006

 

Middle

4.38 (±6.27)

6.68 (±7.32)

1.58 (±3.22)

0.056

 

Lower

3.56 (±5.70)

5.86 (±6.91)

0.75 (±1.15)

0.095

 

Total area

4.24 (±6.05)

6.86 (±7.09)

1.04 (±1.78)

0.012

CD55

Upper

10.80 (±11.93)

15.81 (±13.61)

4.67 (±5.45)

0.012

 

Middle

4.29 (±5.40)

6.46 (±6.11)

1.64 (±2.86)

0.002

 

Lower

5.00 (±6.20)

7.73 (±7.21)

1.66 (±1.88)

0.007

 

Total area

6.70 (±6.59)

10.00 (±7.00)

2.66 (2.92)

0.002

CD38

Upper

5.75 (±4.95)

7.43 (±4.34)

3.68 (±5.10)

0.046

 

Middle

2.86 (±3.94)

3.97 (±4.55)

1.50 (±2.68)

0.038

 

Lower

2.74 (±3.85)

3.60 (±4.52)

1.69 (±2.73)

0.175

 

Total area

3.78 (±4.01)

5.00 (±4.16)

2.29 (±3.47)

0.046

vWF

Upper

4.19 (±2.67)

4.87 (±2.77)

3.37 (±2.43)

0.295

 

Middle

3.84 (±2.92)

4.52 (±2.29)

3.02 (±3.51)

0.175

 

Lower

2.88 (±2.28)

3.46 (±2.39)

2.18 (±2.06)

0.175

 

Total area

3.64 (±2.17)

4.28 (±1.94)

2.86 (±2.30)

0.152

MCT

Upper

1.53 (±1.53)

1.53 (±1.68)

1.54 (±1.42)

0.897

 

Middle

0.58 (±0.79)

0.53 (±0.73)

0.64 (±0.91)

0.696

 

Lower

0.67 (±0.70)

0.66 (±0.59)

0.69 (±0.86)

0.897

 

Total area

0.93 (±0.90)

0.90 (±0.85)

0.96 (±1.01)

0.829

  1. Comparison of rheumatoid arthritis (RA) and osteoarthritis (OA) by Mann–Whitney U, significant results are shown in bold. Upper layer adjacent to lining layer; lower layer with greatest distance from lining layer within the deeper synovium
  2. RA rheumatoid arthritis, OA osteoarthritis, SD standard deviation, CD68 macrophages, CD3 T cells, CD55 synovial fibroblasts, CD38 plasma cells, vWF von Willebrand factor, MCT mast cell tryptase