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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation

Fig. 4

PAD4 contributes to vasculitis in TNF-α-driven lung inflammation. H&E-stained lung sections from 2-, 3.5-, and 5-month-old TNF+PAD4+/+ and TNF+PAD4-/- littermates were scored for the severity of destructive vasculitis. a Representative images of TNF+PAD4+/+ and TNF+PAD4-/- lungs at 5 months of age. Arrows point to vessels with representative amounts of destructive vasculitis. b Average and SEM for severity of destructive vasculitis are shown (2 months old: n = 5 littermate pairs, 3.5 months old: n = 6 TNF+PAD4+/+ and 7 TNF+PAD4-/- mice, 5 months old: n = 10 TNF+PAD4+/+ and 11 TNF+PAD4-/- mice, * p < 0.05). c Five-month-old wild-type littermate lung. Arrow points to representative normal vessel. All images: 200×, bar 0.1 mm. PAD4 peptidylarginine deiminase 4, TNF-α tumor necrosis factor alpha

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