Familial Mediterranean fever is no longer a rare disease in Japan

Table 1 Comparisons of clinical features of between FMF and non-FMF

	FMF	Non-FMF
	n = 192	n = 409	p
Male/female	83/109	133/276	0.011
Age at onset (years), mean ± SD	30.4 ± 39.4	39.4 ± 20.3	<0.0001
Fever	184 (95.8 %)	298 (72.9 %)	<0.0001
Frequencies of febrile attack (per month), mean ± SD	1.06 ± 0.92	0.97 ± 1.11	0.020
Duration of fever attack (days), mean ± SD	3.7 ± 4.0	6.7 ± 8.4	0.001
Abdominal pain	77 (40.1 %)	86 (21.0 %)	<0.0001
Thoracic pain	51 (26.6 %)	24 (5.9 %)	<0.0001
Arthritis	108 (56.3 %)	237 (57.9 %)	0.695
Erysipelas-like erythema	34 (17.7 %)	43 (10.5 %)	0.014
AA amyloidosis	7 (3.6 %)	15 (3.7 %)	0.989
Family history of periodic fever	39 (20.3 %)	25 (6.1 %)	<0.0001
Rheumatic diseases	26 (13.5 %)	186 (45.5 %)	<0.0001

Values are shown as n (%) unless otherwise indicated. AA amyloid A, FMF familial Mediterranean fever

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