Familial Mediterranean fever is no longer a rare disease in Japan

Table 5 Comparisons of clinical features of patients with or without accompanying rheumatic diseases

	FMF
	Rheumatic diseases (+)	Rheumatic diseases (–)
	n = 26	n = 166	p
Male/female	4/22	79/87	0.002
Age at onset (years), mean ± SD	39.3 ± 15.8	29.0 ± 16.8	0.006
Fever	24 (92.3 %)	160 (96.4 %)	0.296
Frequencies of febrile attack (per month), mean ± SD	1.01 ± 0.59	1.06 ± 0.96	0.523
Duration of fever attack (days), mean ± SD	3.0 ± 2.2	3.8 ± 4.1	0.359
Abdominal pain	3 (11.5 %)	74 (44.6 %)	0.001
Thoracic pain	4 (15.4 %)	47 (28.3 %)	0.165
Arthritis	21 (80.8 %)	87 (52.4 %)	0.007
Erysipelas-like erythema	3 (11.5 %)	31 (18.7 %)	0.281
AA amyloidosis	0	7 (4.2 %)	0.355
Family history of periodic fever	1 (3.8 %)	38 (22.9 %)	0.025

Values are shown as n (%) unless otherwise indicated. AA amyloid A, FMF familial Mediterranean fever

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