Skip to main content

Table 3 Correlations of the CgA peptides in TA patients with markers of systemic and local inflammation and with the number of involved vessels

From: Chromogranin-A production and fragmentation in patients with Takayasu arteritis

Whole TA group (N = 42)
  CgA439 CgA-FRs VS-1 CgAtot
 ESR 0.179
n.s.
0.181
n.s.
0.173
n.s.
0.158
n.s.
 CRP 0.015
n.s.
0.326
p = 0.035
0.229
n.s.
0.300
p = 0.053
 PTX3 -0.232
n.s.
-0.082
n.s.
0.291
p = 0.062
0.085
n.s.
 N vessels 0.196
n.s.
0.039
n.s.
-0.047
n.s.
0.066
n.s.
  CgA439/CgAtot CgA-FRs/CgAtot VS-1/CgAtot
 ESR 0.134
n.s.
0.178
n.s.
0.016
n.s.
 CRP -0.009
n.s.
0.088
n.s.
-0.123
n.s.
 PTX3 -0.022
n.s.
-0.123
n.s.
0.154
n.s.
 N vessels 0.153
n.s.
-0.176
n.s.
-0.178
n.s.
TA on PPIs (N = 30)
  CgA439 CgA-FRs VS-1 CgAtot
 ESR 0.119
n.s.
0.045
n.s.
0.010
n.s.
0.002
n.s.
 CRP 0.030
n.s.
0.140
n.s.
0.028
n.s.
0.142
n.s.
 PTX3 -0.258
n.s.
0.065
n.s.
0.176
n.s.
0.071
n.s.
 N vessels 0.309
p = 0.096
0.017
n.s.
-0.009
n.s.
0.076
n.s.
  CgA439/CgAtot CgA-FRs/CgAtot VS-1/CgAtot
 ESR 0.174
n.s.
0.319
p = 0.097
-0.009
n.s.
 CRP 0.106
n.s.
0.200
n.s.
-0.169
n.s.
 PTX3 -0.241
n.s.
0.037
n.s.
0.133
n.s.
 N vessels 0.251
n.s.
-0.194
n.s.
-0.138
n.s.
Normotensive TA (N = 20)
  CgA439 CgA-FRs VS-1 CgAtot
 ESR -0.368
n.s.
-0.028
n.s.
0.415
p = 0.110
-0.162
n.s.
 CRP -0.124
n.s.
0.389
p = 0.090
0.576
p = 0.008
0.346
n.s.
 PTX3 -0.422
p = 0.061
0.030
n.s.
0.386
p = 0.093
-0.003
n.s.
 N vessels -0.074
n.s.
0.088
n.s.
0.029
n.s.
0.082
n.s.
  CgA439/CgAtot CgA-FRs/CgAtot VS-1/CgAtot
 ESR -0.168
n.s.
0.570
p = 0.021
0.684
p = 0.003
 CRP -0.036
n.s.
0.254
n.s.
-0.309
n.s.
 PTX3 -0.435
p = 0.055
0.159
n.s.
0.480
p = 0.032
 N vessels 0.072
n.s.
-0.012
n.s.
-0.057
n.s.
Hypertensive TA (N = 22)
  CgA439 CgA-FRs VS-1 CgAtot
 ESR 0.517
p = 0.020
0.295
n.s.
-0.192
n.s.
0.276
n.s.
 CRP 0.149
n.s.
0.347
n.s.
0.049
n.s.
0.324
n.s.
 PTX3 -0.030
n.s.
0.157
n.s.
0.088
n.s.
0.153
n.s.
 N vessels 0.382
p = 0.076
-0.222
n.s.
-0.259
n.s.
-0.104
n.s.
  CgA439/CgAtot CgA-FRs/CgAtot VS-1/CgAtot
 ESR 0.536
p = 0.015
-0.085
n.s.
-0.561
p = 0.010
 CRP 0.134
n.s.
0.136
n.s.
-0.455
p = 0.033
 PTX3 -0.052
n.s.
-0.082
n.s.
-0.010
n.s.
 N vessels 0.389
p = 0.073
-0.203
n.s.
-0.311
n.s.
  1. Levels of CgA439, CgA-FRs, VS-1 or their ratios to CgAtot were correlated with markers of systemic inflammation (ESR and CRP), of local inflammation (PTX3) and with the number of vessels involved by the disease (N vessels, see “Methods”). The impact of the treatment with PPIs and of arterial hypertension is also considered. The Spearman correlation coefficient and the relative p values are shown
  2. CgA chromogranin-A, TA Takayasu arteritis, CgA 439 full-length CgA (residues 1–439), CgA-FRs fragments of CgA spanning from the N-terminus to the central region but lacking the C-terminal region, VS-1 vasostatin-1, CgA tot total CgA, ESR erythrocyte sedimentation rate, n.s. not significant, CRP C-reactive protein, PTX3 pentraxin-3, PPI proton-pump inhibitor