Table 3 Effect of CGS 21680 in lymphocytes from healthy subjects (n = 20) or SLE patients (n = 20) on different inflammatory mediators

IFN-α

67 ± 4^a

37 ± 3^a

44.39 ± 1.21^d

74 ± 4^a

32 ± 2^a

56.89 ± 1.52^d,*

TNF-α

225 ± 12^a

102 ± 10^a

54.66 ± 1.14^d

227 ± 10^a

79 ± 5^a

64.95 ± 2.33^d,*

IL-6

305 ± 15^a

167 ± 12^a

45.38 ± 1.18^d

322 ± 13^a

105 ± 6^a

67.71 ± 1.25^d,*

IL-1β

294 ± 14^a

198 ± 13^a

32.64 ± 1.02^d

310 ± 11^a

140 ± 7^a

54.20 ± 2.35^d,*

IL-2

36 ± 3^b

21 ± 2^b

41.59 ± 1.08^d

42 ± 3^b

19 ± 2^b

54.59 ± 1.76^d,*

IL-10

2832 ± 112^a

4802 ± 189^a

1.70 ± 0.02^e

2973 ± 104^a

5329 ± 199^a

1.79 ± 0.02^e,**

NF-kB

245 ± 14^c

161 ± 13^c

34.07 ± 1.08^d

266 ± 10^c

150 ± 6^c

43.69 ± 1.47^d,*