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Table 3 Effect of CGS 21680 in lymphocytes from healthy subjects (n = 20) or SLE patients (n = 20) on different inflammatory mediators

From: A2A adenosine receptor upregulation correlates with disease activity in patients with systemic lupus erythematosus

  Healthy subjects SLE patients
Cellular stimulation CGS 21680 (1μM) stimulation % of reduction/fold of increase Cellular stimulation CGS 21680 (1μM) stimulation % of reduction/fold of increase
IFN-α 67 ± 4a 37 ± 3a 44.39 ± 1.21d 74 ± 4a 32 ± 2a 56.89 ± 1.52d,*
TNF-α 225 ± 12a 102 ± 10a 54.66 ± 1.14d 227 ± 10a 79 ± 5a 64.95 ± 2.33d,*
IL-6 305 ± 15a 167 ± 12a 45.38 ± 1.18d 322 ± 13a 105 ± 6a 67.71 ± 1.25d,*
IL-1β 294 ± 14a 198 ± 13a 32.64 ± 1.02d 310 ± 11a 140 ± 7a 54.20 ± 2.35d,*
IL-2 36 ± 3b 21 ± 2b 41.59 ± 1.08d 42 ± 3b 19 ± 2b 54.59 ± 1.76d,*
IL-10 2832 ± 112a 4802 ± 189a 1.70 ± 0.02e 2973 ± 104a 5329 ± 199a 1.79 ± 0.02e,**
NF-kB 245 ± 14c 161 ± 13c 34.07 ± 1.08d 266 ± 10c 150 ± 6c 43.69 ± 1.47d,*
  1. The data are expressed as mean ± SEM; *p < 0.0001 vs healthy subjects; ** p < 0.01 vs healthy subjects
  2. a Cellular stimulation with LPS; values in pg/ml
  3. b Cellular stimulation with PMA + ionomycin; values in pg/ml
  4. c Cellular stimulation with LPS; values in % of controls
  5. d Percentage of reduction
  6. e Fold of increase