Fig. 1

Mean scores at each visit through week 24 for a patient’s global assessment of disease activity, b pain, c physical function, and d fatigue. Broken vertical line indicates the earliest opportunity for rescue medication; patients who did not achieve ≥20 % improvement from baseline in swollen or tender joint count on two consecutive assessments were offered rescue therapy with open-label sarilumab 200 mg every 2 weeks. HAQ-DI health assessment, FACIT-F functional assessment of chronic illness therapy-fatigue questionnaire disability index, MTX methotrexate