Table 3 Association of smoking or HLA-DRB1 SE and anti-CPP3 IgG in pre-symptomatic individuals compared with controls adjusted for age and sex

 –

–

84 (33.6)

90 (49.7)

Reference

 +

–

149 (59.6)

85 (47.0)

2.12 (1.39–3.23)

 –

+

6 (2.4)

2 (1.1)

3.01 (0.58–15.47)

 +

+

11 (4.4)

4 (2.2)

2.83 (0.86–9.40)

 –

–

79 (31.6)

107 (62.6)

Reference

 +

–

154 (61.6)

59 (34.5)

3.55 (2.32–5.42)

 –

+

6 (2.4)

3 (1.8)

2.41 (0.58–10.13)

 +

+

11 (4.4)

2 (1.2)

6.74 (1.43–31.81)