Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis: a cross-sectional study in female patients with joint effusion

Table 3 Association between adipokines and Lequesne index in three different settings

For univariate effects, adipokine associations were assessed separately, adjusting their effects by measurement batch only. For adjusted effects, estimation of adipokine effects was additionally adjusted by potential confounders: age, knee osteoarthritis symptom duration, Kellgren-Lawrence grade (divided into three categories: 1, 2, and 3 + 4 combined), time from recruitment to radiology, waist circumference, percentage of body fat, physical exercise, and tumor necrosis factor α. In the multivariate model, effects were simultaneously estimated using a single model that included previous confounders and all adipokines except omentin (due to high collinearity observed with adiponectin: partial correlation coefficient [PCC] 0.792)
^aMultivariate association for omentin was assessed in an analogous model in which adiponectin was excluded. The PCC after adjustment by measure round was used to assess associations between Lequesne index and adipokines

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