Fig. 4

Change from baseline in mTSS according to baseline mTSS-defined tertiles for ORAL Scan and ORAL Start. ^* p ≤ 0.05; ^** p ≤ 0.001; and ^*** p < 0.0001 vs PBO or MTX. In post hoc analyses, presented values are descriptive. Data presented in Fig. 3 as a Forest plot are presented here as bar graphs, showing that moving from a lower to a higher tertile category indicates an increase in treatment effect. BID twice daily, LS least squares, mTSS van der Heijde modified total Sharp score, MTX methotrexate, PBO placebo, SE standard error