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Table 2 Patient characteristics and leptin responses in cartilage cultures in the whole study population and compared across body mass index subgroups

From: Catabolic and proinflammatory effects of leptin in chondrocytes are regulated by suppressor of cytokine signaling-3

  All Non-obese, BMI <30 kg/m2 Obese, BMI >30 kg/m2  
n = 97 n = 49 n = 48 P
Gender (female/male)a 60/37 26/23 34/14 0.072
Body mass index (kg/m2)b 30.9 (6.1) 26.2 (2.4) 35.7 (4.6) <0.001
Age (years)b 69.8 (10.0) 72.8 (9.7) 66.8 (9.4) 0.003
Synovial fluid leptin (ng/ml)c, d 12.8 (17.8) 7.6 (11.0) 21.5 (26.7) <0.001
Synovial fluid IL-6 (pg/ml)c, d 118.9 (196.0) 126.8 (204.3) 114.0 (280.2) 0.784
Synovial fluid MMP-1 (ng/ml)c, d 14.4 (25.7) 10.4 (16.6) 18.1 (27.3) 0.325
Synovial fluid MMP-3 (ng/ml)c, d 649.5 (929.6) 591.6 (571.0) 764.9 (1159.0) 0.106
Leptin response in cartilage        
MMP-1 (change pg/mg cartilage)c 145.8 (247.1) 123.2 (253.6) 150.0 (258.3) 0.773
MMP-3 (change ng/mg cartilage)c 5.2 (8.8) 6.0 (8.6) 4.9 (10.2) 0.920
MMP-13 (change pg/mg cartilage)c 5.8 (13.6) 6.3 (11.8) 5.4 (15.9) 0.983
IL-6 (change pg/mg cartilage)c 123.2 (310.2) 114.6 (295.1) 130.9 (312.0) 0.740
NO (change pmol/mg cartilage)c 44.5 (133.4) 31.0 (125.8) 52.2 (140.0) 0.359
iNOS (fold of increase)c, e 11.7 (160.6) 5.4 (143.1) 15.2 (209.6) 0.501
COX-2 (fold of increase)c, e 6.9 (18.4) 7.1 (15.0) 6.4 (22.6) 0.748
  1. aValues are numbers of female/male subjects; p value was calculated for comparison between non-obese and obese subjects using the chi-square test. bValues are mean (SD); p values were calculated for comparison between non-obese and obese subjects using the unpaired t test. cValues are median (IQR); p values were calculated for comparison between non-obese and obese subjects using the Mann–Whitney test. dSynovial fluid sample was obtained from 90 patients. eNumbers of patients (non-obese/obese) in the analysis were 26/31 for inducible nitric oxide synthase (iNOS) and 25/29 for cyclooxygenase-2 (COX-2). MMP matrix metalloproteinase, IL interleukin, NO nitric oxide