Fig. 10From: Glucocorticoid-induced leucine zipper (GILZ) is involved in glucocorticoid-induced and mineralocorticoid-induced leptin production by osteoarthritis synovial fibroblastsAbsence of glucocorticoid-induced leucine zipper (GILZ) prevented the corticoid-induced leptin and leptin receptor (Ob-R) expression without modulating the anti-inflammatory properties of glucocorticoids. Prednisolone and aldosterone induced GILZ expression in OA synovial fibroblasts through glucocorticoid receptor (GR) but not mineralocorticoid receptor (MR) activation, whereas Compound A (CpdA) did not. Similar effects on leptin secretion and Ob-R expression were observed. Thus, GILZ was involved in prednisolone-induced and aldosterone-induced leptin secretion and Ob-R expression. In addition, GILZ inhibition did not alter the anti-inflammatory action of prednisoloneBack to article page