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Fig. 10 | Arthritis Research & Therapy

Fig. 10

From: Glucocorticoid-induced leucine zipper (GILZ) is involved in glucocorticoid-induced and mineralocorticoid-induced leptin production by osteoarthritis synovial fibroblasts

Fig. 10

Absence of glucocorticoid-induced leucine zipper (GILZ) prevented the corticoid-induced leptin and leptin receptor (Ob-R) expression without modulating the anti-inflammatory properties of glucocorticoids. Prednisolone and aldosterone induced GILZ expression in OA synovial fibroblasts through glucocorticoid receptor (GR) but not mineralocorticoid receptor (MR) activation, whereas Compound A (CpdA) did not. Similar effects on leptin secretion and Ob-R expression were observed. Thus, GILZ was involved in prednisolone-induced and aldosterone-induced leptin secretion and Ob-R expression. In addition, GILZ inhibition did not alter the anti-inflammatory action of prednisolone

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