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Table 2 Results of statistical analysis of discovery and validation cohorts

From: A discrete cluster of urinary biomarkers discriminates between active systemic lupus erythematosus patients with and without glomerulonephritis

  Discovery cohort Validation cohort
Urinary analyte Log2 fold-difference ALN vs ANLN p adj* p adj* ALN vs ANLN p adj* ALN vs RLN
Adiponectin 4 ≤0.0001 ≤0.0044 ≤0.0018
PAI-1 3.77 ≤0.0001 ≤0.0044 ≤0.0018
IL-15 3.32 ≤0.0001 ≤0.0044 ≤0.0018
PF4 (CXCL4) 3.04 ≤0.0001 ≤0.0044 ≤0.0018
TIMP-1 3.01 ≤0.0001 ≤0.0044 ≤0.0018
IL.16 2.97 ≤0.0001 0.62 N/A
Albumin 2.95 ≤0.0001 0.022 1
MPO 2.62 ≤0.0001 0.81 N/A
vWF 2.5 ≤0.0001 ≤0.0044 ≤0.0018
sVCAM-1 2.49 ≤0.0001 ≤0.0044 ≤0.0018
IL-6 2.46 ≤0.0001 0.0088 ≤0.0018
BCA-1 2.22 ≤0.0001 0.54 N/A
SAP 2.19 0.001 0.33 N/A
KIM-1 1.95 ≤0.0001 0.044 0.013
GRO 1.93 ≤0.0001 ≤0.0044 0.0054
HCC-1 (CCL14a) 1.91 ≤0.0001 ND N/A
SCF 1.89 ≤0.0001 1 N/A
MMP-9 1.89 0.007 1 N/A
Cystatin C 1.87 ≤0.0001 0.044 0.0072
sFas 1.76 ≤0.0001 0.18 N/A
PDGF-BB 1.7 0.005 0.80 N/A
GCP-2 (CXCL6) 1.69 ≤0.0001 ≤0.0044 ≤0.0018
IL-8 1.66 0.002 0.0088 0.26
Clusterin 1.58 ≤0.0001 ≤0.0044 ≤0.0018
Eotaxin 1.58 0.002 1 N/A
MMP-7 1.56 0.002 0.022 ≤0.0018
MMP-2 1.56 ≤0.0001 1 N/A
TARC 1.48 ≤0.0001 1 N/A
HGF 1.47 ≤0.0001 0.44 N/A
NAP-2 (CXCL7) 1.47 0.001 1 N/A
Perforin 1.37 ≤0.0001 1 N/A
MCP-1 1.34 ≤0.0001 ≤0.0044 ≤0.0018
IFNγ 1.29 0.005 1 N/A
GM-CSF 1.24 0.007 0.0088 0.013
Eotaxin-2 1.22 ≤0.0001 1 N/A
TWEAK 1.16 0.001 0.54 N/A
I-TAC (CXCL11) 1.13 0.007 0.079 N/A
sIL-1RI 1.12 0.003 1 N/A
sgp130 1.07 ≤0.0001 1 N/A
sTNFRI 1.06 0.004 1 N/A
MCP-3 1.02 0.006 1 N/A
TIMP-2 1.01 0.002 1 N/A
NGAL 0.95 0.01 ND N/A
VEGF 0.72 0.007 1 N/A
X6CKine –3.15 ≤0.0001 1 N/A
  1. *p values have been adjusted for multiple testing to reduce the false discovery rate
  2. N/A not applicable, ND not determined
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Arthritis Research & Therapy

ISSN: 1478-6362

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