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Table 2 Results of statistical analysis of discovery and validation cohorts

From: A discrete cluster of urinary biomarkers discriminates between active systemic lupus erythematosus patients with and without glomerulonephritis

 

Discovery cohort

Validation cohort

Urinary analyte

Log2 fold-difference ALN vs ANLN

p adj*

p adj* ALN vs ANLN

p adj* ALN vs RLN

Adiponectin

4

≤0.0001

≤0.0044

≤0.0018

PAI-1

3.77

≤0.0001

≤0.0044

≤0.0018

IL-15

3.32

≤0.0001

≤0.0044

≤0.0018

PF4 (CXCL4)

3.04

≤0.0001

≤0.0044

≤0.0018

TIMP-1

3.01

≤0.0001

≤0.0044

≤0.0018

IL.16

2.97

≤0.0001

0.62

N/A

Albumin

2.95

≤0.0001

0.022

1

MPO

2.62

≤0.0001

0.81

N/A

vWF

2.5

≤0.0001

≤0.0044

≤0.0018

sVCAM-1

2.49

≤0.0001

≤0.0044

≤0.0018

IL-6

2.46

≤0.0001

0.0088

≤0.0018

BCA-1

2.22

≤0.0001

0.54

N/A

SAP

2.19

0.001

0.33

N/A

KIM-1

1.95

≤0.0001

0.044

0.013

GRO

1.93

≤0.0001

≤0.0044

0.0054

HCC-1 (CCL14a)

1.91

≤0.0001

ND

N/A

SCF

1.89

≤0.0001

1

N/A

MMP-9

1.89

0.007

1

N/A

Cystatin C

1.87

≤0.0001

0.044

0.0072

sFas

1.76

≤0.0001

0.18

N/A

PDGF-BB

1.7

0.005

0.80

N/A

GCP-2 (CXCL6)

1.69

≤0.0001

≤0.0044

≤0.0018

IL-8

1.66

0.002

0.0088

0.26

Clusterin

1.58

≤0.0001

≤0.0044

≤0.0018

Eotaxin

1.58

0.002

1

N/A

MMP-7

1.56

0.002

0.022

≤0.0018

MMP-2

1.56

≤0.0001

1

N/A

TARC

1.48

≤0.0001

1

N/A

HGF

1.47

≤0.0001

0.44

N/A

NAP-2 (CXCL7)

1.47

0.001

1

N/A

Perforin

1.37

≤0.0001

1

N/A

MCP-1

1.34

≤0.0001

≤0.0044

≤0.0018

IFNγ

1.29

0.005

1

N/A

GM-CSF

1.24

0.007

0.0088

0.013

Eotaxin-2

1.22

≤0.0001

1

N/A

TWEAK

1.16

0.001

0.54

N/A

I-TAC (CXCL11)

1.13

0.007

0.079

N/A

sIL-1RI

1.12

0.003

1

N/A

sgp130

1.07

≤0.0001

1

N/A

sTNFRI

1.06

0.004

1

N/A

MCP-3

1.02

0.006

1

N/A

TIMP-2

1.01

0.002

1

N/A

NGAL

0.95

0.01

ND

N/A

VEGF

0.72

0.007

1

N/A

X6CKine

–3.15

≤0.0001

1

N/A

  1. *p values have been adjusted for multiple testing to reduce the false discovery rate
  2. N/A not applicable, ND not determined