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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: A specific anti-citrullinated protein antibody profile identifies a group of rheumatoid arthritis patients with a toll-like receptor 4-mediated disease

Fig. 4

Anti-citrullinated protein antibodies (ACPA) fine specificity in the synovial fluid samples of patients with rheumatoid arthritis and their correlation with NI-0101 response. Antibody reactivity against the citrullinated peptides derived from fibrinogen-α (cFbα − pept), fibrinogen-β (cFbβ-pept) and histone-2A (cH2A-pept) were determined by ELISA and expression in synovial fluids was measured in ACPA-positive rheumatoid arthritis synovial fluid (RASF) samples (a) (n = 22) and both ACPA-negative and ACPA-positive RASF samples (b) (n = 40). RASF samples were classified as NI-0101 non-responders (NR) or NI-0101 responders (R). The Mann-Whitney U test was performed to compare observed changes; ***p < 0.001, **p < 0.01, *p < 0.05

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Arthritis Research & Therapy

ISSN: 1478-6362

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