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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: A specific anti-citrullinated protein antibody profile identifies a group of rheumatoid arthritis patients with a toll-like receptor 4-mediated disease

Fig. 5

Anti-citrullinated protein antibodies (ACPA) fine specificity in paired sera samples of patients with rheumatoid arthritis (RA) and their correlation with RA synovial fluid (RASF) response to NI-0101. a Correlation between ACPA in paired samples of sera from patients with RA and synovial fluids (n = 22). b ACPA in paired samples of sera from patients with RA classified according to RASF response to NI-0101 (NI-0101 non-responders (NR) or NI-0101 responders (R)). c, d Antibody reactivity against the citrullinated peptides derived from fibrinogen-α (cFbα-pept), fibrinogen-β (cFbβ-pept) and histone-2A (cH2A-pept) were determined by ELISA in paired samples of sera from patients with RA and correlation with response to NI-0101 was tested. c Paired sera samples from ACPA-positive patients with RA (n = 13). d Paired samples of sera from from ACPA-positive and ACPA-negative patients with RA (n = 22). The Mann-Whitney U test was performed to compare observed changes; **p < 0.01, *p < 0.05

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Arthritis Research & Therapy

ISSN: 1478-6362

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