|
Baseline demographic and disease parameters
|
|
Age, mean ± SD, years
|
54.7 ± 13.1
|
49.8 ± 12.7
|
48.4 ± 12.8
|
51.0 ± 13.1
|
|
Sex, female, %
|
75.6
|
84.8
|
80.0
|
80.1
|
|
Duration of RA, mean ± SD, years
|
8.0 ± 8.6
|
7.1 ± 6.7
|
6.4 ± 6.4
|
7.2 ± 7.3
|
|
Anti-CCP antibody positive, %b
|
73.7
|
95.0
|
90.0
|
86.4
|
|
Rheumatoid factor positive, %
|
66.7
|
87.0
|
88.9
|
80.9
|
|
Tender joint count, mean ± SD
|
27.9 ± 17.0
|
28.1 ± 17.2
|
26.9 ± 14.6
|
27.7 ± 16.2
|
|
Swollen joint count, mean ± SD
|
17.6 ± 12.3
|
18.3 ± 10.9
|
17.2 ± 9.3
|
17.7 ± 10.8
|
|
CRP, mean ± SD, mg/dL
|
2.8 ± 2.8
|
2.6 ± 2.8
|
3.4 ± 4.4
|
3.0 ± 3.4
|
|
Baseline biomarker serum concentrations, median (quartile 1/quartile 3)
|
|
C1M, ng/mL
|
198.1 (132.0/263.4)
|
179.6 (140.2/235.8)
|
172.3 (132.4/273.0)
|
179.6 (133.5/259.3)
|
|
C2M, ng/mL
|
0.2 (0.2/0.3)
|
0.3 (0.2/0.3)
|
0.2 (0.2/0.4)
|
0.2 (0.2/0.3)
|
|
C3M, ng/mL
|
45.6 (38.9/58.1)
|
47.6 (38.3/60.2)
|
47.9 (37.9/59.3)
|
47.5 (38.3/59.0)
|
|
CRPM, ng/mL
|
17.3 (12.1/21.7)
|
16.5 (14.1/21.4)
|
16.3 (13.9/22.3)
|
16.7 (13.1/21.7)
|
