Fig. 1
From: Screening for peptides targeted to IL-7Rα for molecular imaging of rheumatoid arthritis synovium
Apparent dissociation constant (K d ) values of the synthesized selected peptides and of IL-7 were determined for their binding to IL-7 receptor (IL-7R) and fibronectin (FN) (a). The ratio between Kd values for FN over IL-7R binding are shown (b). The binding of peptides P725 (c) and P258 (d) to Jurkat cells stimulated by 5-Aza-2′-deoxycytidine was compared to anti-IL-7R antibody (e and f), which co-localizes with peptides as shown by their superposition (g and h). Peptide annotation: P722 C-PHPQRPA-C, P725 C-KIMKSMP-C, P726 C-ASACPPH-C, P258 ASACPPH