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Table 3 Pharmacokinetic parameters of USPIO-P258 in comparison to USPIO-PEG, as determined in healthy NMRI mice

From: Screening for peptides targeted to IL-7Rα for molecular imaging of rheumatoid arthritis synovium

Pharmacokinetic parameters USPIO-P258 USPIO-PEG
Te1/2 (minutes) 118 284
VDss (L/kg) 0.100 0.0475
Cltot (mL/min/kg) 0.595 0.116
  1. USPIO ultra-small superparamagnetic particles of iron oxide, PEG poly(ethylene glycol), T e1/2 elimination half-life, VDss volume of distribution steady state, Cltot total clearance