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Fig. 12 | Arthritis Research & Therapy

Fig. 12

From: Rheumatoid arthritis antigens homocitrulline and citrulline are generated by local myeloperoxidase and peptidyl arginine deiminases 2, 3 and 4 in rheumatoid nodule and synovial tissue

Fig. 12

PAD4 co-localization with citrulline- and homocitrulline-binding F95 antibody and macrophage marker KP1 (CD68) in the intact tissue adjacent necrosis in rheumatoid nodule. PAD4 HIER was performed in pH 6 citrate buffer. PAD4 and F95 bound abundantly to the nucleuses and somewhat to the cytoplasm of cells surrounding the necrotic area. No nuclear staining was detected in the cells adjacent to necrosis. PAD4 co-localized with KP1 in the cells surrounding necrosis. Asterisk necrosis, double-headed arrow palisading histiocytes

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Arthritis Research & Therapy

ISSN: 1478-6362

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