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Table 2 Correlations between lymph node indices and patient characteristics at baseline

From: Power Doppler ultrasonographic assessment of the joint-draining lymph node complex in rheumatoid arthritis: a prospective, proof-of-concept study on treatment with tumor necrosis factor inhibitors

 

Spearman’s rho correlation coefficient (95 % CI)

LNV index

LNCW index

LNPD index

Autoimmune status

 IgG ACPA (U/ml)a

−0.07 (−0.38 to 0.25)

p = 0.677

−0.16 (−0.45 to 0.16)

p = 0.321

−0.04 (−0.35 to 0.27)

p = 0.790

 (ACPA-positive patients)

0.04 (−0.41 to 0.47)

p = 0.874

−0.20 (−0.59 to 0.27)

p = 0.402

−0.12 (−0.54 to 0.34)

p = 0.605

 IgM RF (U/ml)

−0.01 (−0.33 to 0.30)

p = 0.936

0.05 (−0.27 to 0.36)

p = 0.752

0.09 (−0.23 to 0.40)

p = 0.568

 (RF-positive patients)

0.08 (−0.40 to 0.52)

p = 0.760

0.20 (−0.29 to 0.61)

p = 0.414

0.23 (−0.27 to 0.63)

p = 0.361

Joint assessment—clinical

 TJC28

0.01 (−0.30 to 0.33)

p = 0.945

0.01 (−0.30 to 0.33)

p = 0.929

−0.02 (−0.33 to 0.30)

p = 0.910

 TJC (ipsilateral)b, c

−0.02 (−0.34 to 0.29)

p = 0.876

0.00 (−0.32 to 0.31)

p = 0.994

−0.07 (−0.38 to 0.25)

p = 0.656

 SJC28

0.14 (−0.18 to 0.44)

p = 0.394

0.24 (−0.08 to 0.52)

p = 0.142

0.24 (−0.08 to 0.51)

p = 0.147

 SJC (ipsilateral)b, c

0.15 (−0.17 to 0.44)

p = 0.366

0.25 (−0.07 to 0.53)

p = 0.121

0.21 (−0.11 to 0.50)

p = 0.189

Joint assessment—PDUS

 12-joint GS index

0.30 (−0.02 to 0.56)

p = 0.063

0.33 (0.02–0.59)

p  = 0.039

0.36 (0.05–0.60)

p  = 0.026

 GS index (ipsilateral)b

0.15 (−0.17 to 0.45)

p = 0.347

0.39 (0.08–0.62)

p  = 0.015

0.25 (−0.06 to 0.53)

p = 0.117

 GS index (contralateral)

0.05 (−0.27 to 0.36)

p = 0.767

0.21 (−0.11 to 0.49)

p = 0.204

0.14 (−0.18 to 0.44)

p = 0.392

 12-joint PD index

0.46 (0.17–0.68)

p  = 0.003

0.31 (0.00–0.57)

p = 0.053

0.35 (0.04–0.60)

p  = 0.029

 PD index (ipsilateral)b

0.40 (0.10–0.64)

p  = 0.011

0.42 (0.12–0.65)

p  = 0.007

0.36 (0.05–0.61)

p  = 0.024

 PD index (contralateral)

0.16 (−0.17 to 0.45)

p = 0.340

0.16 (−0.17 to 0.45)

p = 0.342

0.19 (−0.13 to 0.48)

p = 0.235

  1. p <0.05 values are highlighted bold
  2. aACPA titers >340 U/ml were not further diluted
  3. bCorrelations between LN and joint parameters in nondominant arm
  4. cJoint count restricted to I–V metacarpophalangeal joints, I–IV proximal and thumb interphalangeal joints, wrist, elbow, shoulder
  5. CI confidence interval, LNV lymph node volume, LNCW lymph node cortical width, LNPD lymph node power Doppler, ACPA anti-citrullinated peptide antibodies, RF rheumatoid factor, TJC28 tender joint count in 28 joints, SJC28 swollen joint count in 28 joints, PDUS power Doppler ultrasonography, GS gray scale, PD power Doppler